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Epilepsy in Patients with Multiple Sclerosis: Radiological‐Clinical Correlations
Author(s) -
Moreau Th.,
Sochurkova D.,
Lemesle M.,
Madinier G.,
Billiar Th.,
Giroud M.,
Dumas R.
Publication year - 1998
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1998.tb01187.x
Subject(s) - multiple sclerosis , epilepsy , magnetic resonance imaging , medicine , neurology , atrophy , pediatrics , psychology , pathology , radiology , psychiatry
Summary:Purpose: To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS). Methods: Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population. Results: In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs). Conclusions : Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.