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Anticonvulsant Action of Gabapentin During Postnatal Development in Rats
Author(s) -
Mareš Pavel,
Haugvicova Renata
Publication year - 1997
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1997.tb01254.x
Subject(s) - gabapentin , anticonvulsant , action (physics) , epilepsy , medicine , pharmacology , neuroscience , anesthesia , psychology , physics , alternative medicine , pathology , quantum mechanics
Summary : Purpose: To study the anticonvulsant effects of gabapentin (GBP) in immature animals. Methods : Motor seizures were induced by pentylenetetrazol in 7‐, 12‐, 18‐, 25‐day‐old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic‐clonic (GTCS) were recorded, and seizure severity was scored. Results : GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18‐day‐old rats. Both effects exhibited a tendency to a U‐shaped dose‐response curve. Conclusions : Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.