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Pharmacokinetics of New Antiepileptic Drugs
Author(s) -
Gram Lennart
Publication year - 1996
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1996.tb06034.x
Subject(s) - oxcarbazepine , felbamate , lamotrigine , vigabatrin , tiagabine , pharmacokinetics , topiramate , anticonvulsant , medicine , pharmacology , gabapentin , antiepileptic drug , dosing , epilepsy , carbamazepine , psychiatry , alternative medicine , pathology
Summary: This article surveys the pharmacokinetic parameters for the new antiepileptic drugs (AEDs): felba‐mate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin. Compared to the pharmaco kinetics of standard AEDs, these new AEDs have progressed in terms of (a) longer half‐lives, permitting once‐or twice‐daily dosing, (b) greatly reduced potential for drug interactions, thus increasing ease of treatment, and (c) general lack of hepatic enzyme induction, which facilitates polytherapy as well as other aspects of treatment.