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Neuron‐Specific Enolase Is Increased After Single Seizures During Inpatient Video/EEG Monitoring
Author(s) -
Rabinowicz Adrian L.,
Correale Jorge,
Boutros Raja B.,
Couldwell William T.,
Henderson Carlton W.,
DeGiorgio Christopher M.
Publication year - 1996
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1996.tb00002.x
Subject(s) - enolase , epilepsy , ictal , electroencephalography , anesthesia , medicine , tonic (physiology) , central nervous system disease , psychology , neuroscience , immunohistochemistry
Summary: Neuron‐specific enolase (NSE) is a marker of brain injury after acute neurologic insults. We report changes in serum NSE (s‐NSE) in 25 patients (15 with epilepsy and 10 patients with nonepileptic events) during continuous inpatient video/EEG monitoring. s‐NSE was significantly increased as compared with baseline and normal controls after the first ictal event in the epileptic group, especially in patients with secondarily generalized tonic‐clonic seizures (p = 0.01), but s‐NSE was not increased in patients with nonepileptic events. These preliminary data indicate that s‐NSE may be increased after complex partial seizures‐and generalized tonic‐clonic seizures (GTCS).