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Comparative Anticonvulsant Activity and Neurotoxicity of 4–Amino‐ N ‐(2,6‐Dimethylphenyl)Phthalimide and Prototype Antiepileptic Drugs in Mice and Rats
Author(s) -
Bailleux Vincent,
Vallée Louis,
Nuyts JeanPierre,
Hamoir Gaëtane,
Poupaert Jacques H.,
Stables James P.,
Vamecq Joseph
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb02567.x
Subject(s) - pentylenetetrazol , anticonvulsant , ethosuximide , carbamazepine , pharmacology , phenytoin , felbamate , primidone , chemistry , phenobarbital , neurotoxicity , ed50 , epilepsy , picrotoxin , medicine , toxicity , biochemistry , antagonist , organic chemistry , psychiatry , in vitro , receptor
Summary: We compared the anticonvulsant activity and neurotoxicity of 4‐amino‐ N ‐(2,6–dimethyl‐phenyl)phthalimide (ADD213063)with those of phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), ethosuximide (ESM), valproate (VPA), and felbamate (FBM). Evaluation of anticonvulsant properties performed according to well‐established procedures in rats and mice showed that ADD 213063 is most effective in protecting animals against maximal electroshock seizures (MES). This anti‐MES activity is achieved with nontoxic doses, with the optimal effect recorded in rats dosed orally with anti‐MES ED, and protective index (PI) values of 25.2 FmoYkg and >75, respectively. ADD 213063 protects to a lesser extent against seizures induced by subcutaneous (s.c.) picrotoxin and subcutaneous pentylenetetrazol(FTZ) in mice dosed intraperitoneally and orally, respectively. The profile of anticonvulsant action of ADD 213063 closely parallels that of CBZ.