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Propofol in Prehospital Treatment of Convulsive Status Epilepticus
Author(s) -
Kuisma Markku,
Roine Risto O.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb01069.x
Subject(s) - status epilepticus , propofol , medicine , anesthesia , epilepsy , psychiatry
Summary: We studied the safety and efficacy of intravenous propofol in the out–of–hospital treatment of convulsive status epilepticus (SE) in 8 patients (age 29–70 years), 4 of them with posttraumatic epilepsy. Four patients had no history of seizures. Convulsions ceased promptly after patients received a bolus of 100–200 mg propofol administered before hospital admission by staff of a mobile intensive care unit (ICU). The median duration of coma was 3 h 15 min (range 2–41 h), and the median duration of hospital treatment was 3 1/2 days (range 12 h to 23 days). Only 1 patient was admitted to the hospital's ICU. No adverse effects were observed except for a transient decrease in systolic blood pressure (SBP). Propofol may be a useful drug for the prehospital treatment of recurrent seizures not responding to intravenous diazepam (DZP).