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Gabapentin Toxicity in Children Manifesting as Behavioral Changes
Author(s) -
Wolf Steven M.,
Shinnar Shlomo,
Kang Harriet,
Gil Karen Ballaban,
Moshé Solomon L.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb01063.x
Subject(s) - gabapentin , discontinuation , antiepileptic drug , anticonvulsant , psychology , medicine , epilepsy , toxicity , pediatrics , partial seizures , anesthesia , psychiatry , alternative medicine , pathology
Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.