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Cytokine Production in Blood Mononuclear Cells from Epileptic Patients
Author(s) -
Pacifici R.,
Paris L.,
Carlo S.,
Bacosi A.,
Pichini S.,
Zuccaro P.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb01013.x
Subject(s) - peripheral blood mononuclear cell , cytokine , medicine , epilepsy , phenobarbital , carbamazepine , stimulation , interleukin , immunology , alpha (finance) , immune system , interleukin 2 , pharmacology , endocrinology , in vitro , biology , surgery , biochemistry , psychiatry , construct validity , patient satisfaction
Summary Although convulsive disorders have been associated with immune abnormalities, little is known about cytokine production in epileptic patients. We evaluated the concentrations of interleukin‐1α (IL‐1α), interleukin‐1β (IL‐1β), interleukin‐2 (IL‐2), and interleukin‐6 (IL‐6) secreted by peripheral blood mononuclear cells (PBMC) from epileptic patients. The PBMC collected from epileptic patients, as compared with those of a control group, showed greater production of IL‐1α, IL‐1β, and IL‐6 in response to in vitro stimulation with mitogen. There was no statistical difference among patients treated with different antiepileptic drugs (AEDs). Significantly greater IL‐2 production was observed in PBMC from carbamazepine (CBZ)‐treated patients as compared with both the control group or with valproate and phenobarbital (PB)‐treated patients.