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Carbamazepine, Phenytoin, Sex Hormones, and Sexual Function in Men with Epilepsy
Author(s) -
Isojarvi Jouko I. T.,
Repo Marja,
Pakarinen Arto J.,
Lukkarinen Olavi,
Myllylä Vilho V.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb01011.x
Subject(s) - sex hormone binding globulin , carbamazepine , phenytoin , epilepsy , medicine , endocrinology , androgen , hormone , free androgen index , sexual function , anticonvulsant , psychiatry
Summary We evaluated the effects of carbamazepine (CBZ) on serum androgen levels and sexual function prospectively for 5 years in 11 men with epilepsy and in 25 patients receiving either CBZ (14 patients) or phenytoin (PHT) (11) monotherapy for >5 years. Serum sex hormone binding globulin (SHBG) levels increased and free androgen index (FAI) decreased during CBZ treatment, and these changes correlated with duration of CBZ therapy. Similarly, serum SHBG levels increased and FA1 values decreased in patients receiving PHT for >5 years. CBZ and PHT increase serum SHBG levels, leading to decreased FAI. These drugrelated hormonal changes may be the primary cause of hyposexuality common in men with epilepsy.