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High‐Dose Tamoxifen in Treatment of Brain Tumors: Interaction with Antiepileptic Drugs
Author(s) -
Rabinowicz Adrian L.,
Hinton David R.,
Dyck Peter,
Couldwell William T.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb00494.x
Subject(s) - tamoxifen , medicine , antiepileptic drug , epilepsy , anticonvulsant , pharmacology , psychiatry , cancer , breast cancer
Summary: The incidence of seizures related to primary brain tumors is 20–80%. High‐dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies. Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction. We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high‐dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high‐dose tamoxifen therapy is instituted.