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Near‐Patient Rapid Assay of Phenytoin Concentration
Author(s) -
Scheyer Richard D.,
Hochholzer Jane M.,
Mattson Richard H.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb00475.x
Subject(s) - phenytoin , medicine , anticonvulsant , clinical neurology , chemistry , epilepsy , pharmacology , chromatography , neuroscience , psychology , psychiatry
Summary: The Biotrack 516 is a simple, automated whole blood phenytoin (PHT) assay that reports corresponding total serum concentrations in 3 min. We compared Biotrack results in 58 patients with the total and unbound serum PHT concentrations measured by the standard TDx fluorescence polarization immunoassay. Correlation with total TDx concentration was high (r = 0.98); median absolute error was 1.4 μg/ml. Correlation of unbound PHT with Biotrack (r = 0.95) was comparable to correlation of unbound and total TDx (r = 0.94). The Biotrack assay is a promising method for clinical monitoring of PHT concentrations.