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Complexity of Focal Spikes Suggests Relative Epileptogenicity
Author(s) -
Rodin Ernst,
Litzinger M.,
Thompson J.
Publication year - 1995
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1995.tb00465.x
Subject(s) - neuroscience , epilepsy , spike (software development) , audiology , psychology , medicine , pathology , computer science , software engineering
Summary: The EEGs of 39 children with focal or multifocal spikes were subjected to singular value decomposition (SVD) as provided by a commercial software program. We noted that in children with spikes but no clinical seizures the variance accounted for by the first component averaged 91.9%, whereas in children with seizures it was 68.0% (p < .001). The first component accounted for 85.4% in children with single spike foci, for 71.5% in those with multifocal spikes, and for 61.4% (p < 0.002) in those with both focal spikes and generalized spike‐wave complexes. Spikes in the frontal and frontopolar areas were the most complex, suggesting that at least in children they tend to be the partial expression of a generalized seizure tendency rather than a result of strictly local pathology.