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Tiagabine
Author(s) -
Mengel Helle
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb05976.x
Subject(s) - tiagabine , anticonvulsant , epilepsy , antiepileptic drug , pharmacology , mechanism of action , partial seizures , medicine , partial epilepsy , drug , chemistry , biochemistry , psychiatry , in vitro
Summary: Tiagabine (TGB), a specific γ‐aminobutyric acid (GABA)‐uptake inhibitor, is a potential new antiepileptic drug with a novel mechanism of action. In animal models of epilepsy as well as in a placebo‐controlled trial in patients with complex partial seizures, TGB showed significant anticonvulsant effects. TGB was well tolerated by most patients.