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Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy
Author(s) -
Mattson Richard H.,
Petroff Ognen,
Rothman Douglas,
Behar Kevin
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb05963.x
Subject(s) - vigabatrin , nuclear magnetic resonance , neuroscience , human brain , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , medicine , anticonvulsant , epilepsy , psychology , physics , radiology
Summary: Vigabatrin (VGB, Sabril) is a new antiepileptic drug used for treatment of partial and secondarily generalized tonic‐clonic seizures. Many controlled short‐ and long‐term trials have established efficacy as add‐on therapy. Side effects have been infrequent. VGB acts as an irreversible substrate for 7‐aminobutyric acid (GABA) transaminase that leads to elevated brain GABA levels. Although this mechanism has been confirmed in animals and in cerebrospinal fluid of humans, we report the first study of brain GABA levels using noninvasive nuclear magnetic resonance spectroscopy. GABA elevation in brain closely parallels VGB dosage and reaches concentrations 2–3 times control values at daily dosage of 3 g. This technique offers promising potential to monitor changes induced by VGB as a function of time, dose, and clinical effect.