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Systemic Lupus Erythematosus Associated with Use of Valproate
Author(s) -
Asconapé Jorge J.,
Manning Kenneth R.,
Lancman Marcelo E.
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02927.x
Subject(s) - prednisone , medicine , leukopenia , dose , epilepsy , anemia , lupus erythematosus , pediatrics , gastroenterology , antibody , immunology , chemotherapy , psychiatry
Summary: A 30‐year‐old man with long‐standing localization‐related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic lowgrade hemolytic anemia. Pertinent laboratory results included positive ANA, rheumatoid factor, anti‐NIA, circulating immune complexes, and antihistone antibody. The patient was treated with high dosage prednisone with partial improvement, but continued to have exacerbations at lower dosages. Fourteen months later, VPA was discontinued, and rapid improvement ensued. Prednisone was subsequently discontinued, and the patient has now maintained normal platelet counts for 18 months.