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Disposition of Carbamazepine and Phenytoin in Pregnancy
Author(s) -
Tomson Torbjörn,
Lindbom Ulla,
Ekqvist Britta,
Sundqvist Anders
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02922.x
Subject(s) - carbamazepine , phenytoin , pharmacokinetics , anticonvulsant , pregnancy , metabolite , plasma concentration , metabolic clearance rate , plasma clearance , disposition , first trimester , medicine , chemistry , postpartum period , pharmacology , gestation , epilepsy , psychology , social psychology , psychiatry , biology , genetics
Summary: Free and total plasma concentrations of phenytoin (PHT) and carbamazepine (CBZ) and its active metabolite carbamazepine‐10,11‐epoxide (CBZ‐E) were determined in a prospective study of 86 pregnant epileptic women. The pharmacokinetics of PHT and CBZ during the three trimesters were compared with kinetics at least 10 weeks postpartum. Plasma clearance and unbound CBZ clearance were slightly decreased during the last trimester. Total and free plasma CBZ‐E concentrations did not change significantly during pregnancy. Plasma PHT clearance, on the other hand, increased from the first trimester. A less pronounced increase was observed for clearance of unbound PHT; the increase was statistically significant only during the third trimester.