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Infantile Spasms: Localized Cerebral Lesions on SPECT
Author(s) -
Miyazaki Masahito,
Hashimoto Toshiaki,
Fujii Emiko,
Tayama Masanobu,
Kuroda Yasuhiro
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02543.x
Subject(s) - medicine , epilepsy , clinical neurology , vigabatrin , neuroscience , psychology , psychiatry , anticonvulsant
Summary: Ten infantile spasms (IS) patients had single photon emission computed tomography (SPECT) with [ 99m Tc]HMPAO, EEG, and magnetic resonance imaging (MRI) studies. SPECT showed localized cerebral hypo‐perfusion in 7 infants (4 unifocal; 3 multifocal) always involving the temporal regions either unilaterally or bilaterally. EEGs obtained in near time of the SPECT studies showed focal abnormalities in all 7 infants with hypoper‐fusion on SPECT, with complete correspondence of the abnormalities in 5. MRI showed localized cerebral lesionsin only 3 of the 10 infants, all of whom had corresponding areas of hypoperfusion on SPECT. Our study indicates that localized cerebral abnormalities (especially of the temporal lobes) may often be associated with IS and that such patients may have localized cerebral hypoperfusion on SPECT even when the MRI is normal.