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Role of 5‐Hydroxytryptamine Receptor Subtypes in the 1‐[3‐(Trifluoromethyl)Phenyl] Piperazine‐Induced Increase in Threshold for Maximal Electroconvulsions in Mice
Author(s) -
Przegaliński Edmund,
Baran Leokadia,
Siwanowicz Joanna
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02528.x
Subject(s) - ritanserin , ketanserin , pindolol , prazosin , piperazine , chemistry , agonist , spiperone , serotonin agonist , stimulation , endocrinology , 5 ht receptor , medicine , pharmacology , receptor , serotonin , antagonist , biochemistry
Summary: The effect of l‐[3‐(trifluoromethyl)phenyl] piperazine (TFMPP), a 5‐hydroxytryptamine (5‐HT) receptor agonist, on the threshold for maximal electroconvulsions was studied in mice. TFMPP in intraperitoneal (Lp.) doses of 10, 20 and 40 mg/kg increased the convulsive threshold (the amperage necessary to produce the hindlegtonic extensor component of seizures in 50% of animals) by 28, 60, and 85%, respectively. The effect of TFMPP (20 mg/kg) was dose‐dependently blocked by 142‐methoxyphenyl)‐4‐[4‐(2‐phthalimido)butyl] piperazine (NAN‐190), prazosin, spiperone, mesulergine, ketanserin, and ritanserin. On the other hand, pindolol and cyanopindolol had no effect on the convulsive threshold increased by TFMPP. The results indicate that the TFMPP‐induced decrease in the susceptibility to seizures is connected to stimulation of 5‐HT 2 or of both 5‐HT 1c and 5‐HT 2 receptors. Moreover, α 1 ‐adrenoceptors also appear to be engaged in this effect.