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Reversible Valproate‐Induced Extrapyramidal Disorders
Author(s) -
Sasso Enrico,
Delsoldato Simona,
Negrotti Anna,
Mancia Domenico
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02449.x
Subject(s) - parkinsonism , extrapyramidal disorder , epilepsy , medicine , pathophysiology , extrapyramidal symptoms , central nervous system disease , disease , psychology , pediatrics , psychiatry , schizophrenia (object oriented programming) , antipsychotic
Summary: We observed transient parkinsonism in 2 young epileptic patients with valproate (VPA) therapy. Complete recovery from extrapyramidal disorder occurred spontaneously in a few weeks. The lack of apparent susceptibility related to age and to VPA dosage, the rapid recovery from the extrapyramidal reaction, and the prevalence of negative signs such as bradykinesia and bradyphrenia can be considered the main clinical findings of this disease process. Pathophysiologic mechanisms of this rare “toxic” reaction remain unknown, although a transient imbalance between functionally reciprocal subgroups of GABA pathways leading to remediable dopa‐mine inhibition might be hypothesized.