Premium
Lamotrigine in Treatment of 120 Children with Epilepsy
Author(s) -
Schlumberger E.,
Chavez F.,
Palacios L.,
Rey E.,
Pajot N.,
Dulac O.
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02445.x
Subject(s) - lamotrigine , epilepsy , medicine , vigabatrin , anticonvulsant , pediatrics , psychiatry
Summary: One hundred twenty children aged 10 months to 16 years 9 months were included in three studies with lamotrigine (LTG): a single‐blind study (n = 60), a pharmacokinetic study (n = 23), and a compassionate group (n = 37). At 3 months, 11 patients had become seizure‐free and 34 had >50% decrease in seizure frequency. The best results involved absence epilepsy, Lennox‐Gastaut syndrome (LGS), and other symptomatic generalized epilepsy. Forty‐two patients were followed > 1 year, 22 for a mean of 2.2 years, and there was no significant increase in seizure frequency as compared with 3‐month follow‐up. Fourteen patients became seizure‐free for >6 months; all except 1 had generalized epilepsy. For 12 patients, treatment could be reduced to monotherapy, but for those with valproate (VPA) comedication LTG dosage had to be increased; 25% of patients with VPA monotherapy exhibited skin rash, appearing 3–18 days after starting LTG. For 4 patients, LTG could be reintroduced after VPA was withdrawn. Ten patients had ataxia and/or drowsiness and 2 had vomiting. For all other patients, tolerance was excellent.