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Rapid Arrest of Seizures with an Inhalation Aerosol Containing Diazepam
Author(s) -
Xi Liu Yu,
Zheng Wang Ming,
Zhen Sun Mei,
Xian Niao Shu
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb02444.x
Subject(s) - diazepam , anesthesia , inhalation , medicine , aerosol , chemistry , organic chemistry
Summary: Diazepam (DZP) and a mixture of Chinese herbs customarily used to treat epilepsy were prepared as an aerosol under the trade name Aerosolum Diaiepami Compositae or Flvalscop (FVS). FVS was studied in a single‐blind trial in 101 patients with seizures preceded by an aura and in 19 without an aura to whom was administered by another person. FVS or a control preparation was administered. In 16–22 s, (average 18.5 s), the aura was interrupted and no seizure ensued in 90% of the cases treated with FVS and in 26% of cases treated with the control preparation. Of the 120 patients, 8 had elementary partial seizures with Jacksonian march, 18 had complex partial seizures (CPS), 7 had simple partial seizures with autonomic symptoms, and 87 had secondarily generalized tonic‐clonic seizures. Eleven patients have now received FVS for 2 years (400 ml each). Forty patients for 1 year (150–200 ml each); none of these patients have shown any side effects or abnormal laboratory findings. An aerosol‐administered drug may be a valuable adjunct to the antiepileptic drug (AED) arsenal and merits more extensive evaluation.