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Functional Magnetic Resonance Imaging in Partial Epilepsy
Author(s) -
Morris George Lee,
Mueller W. M.,
Yetkin F. Z.,
Haughton V. M.,
Hammeke T. A.,
Swanson S.,
Rao S. M.,
Jesmanowicz A.,
Estkowski L. D.,
Bandettini P. A.,
Wong E. C.,
Hyde J. S.
Publication year - 1994
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1994.tb01788.x
Subject(s) - functional magnetic resonance imaging , postcentral gyrus , neuroscience , epilepsy , cerebral blood flow , cerebrum , magnetic resonance imaging , eeg fmri , functional magnetic resonance spectroscopy of the brain , psychology , brain activity and meditation , brain mapping , functional imaging , premovement neuronal activity , neuroimaging , human brain , supplementary motor area , medicine , electroencephalography , cardiology , central nervous system , radiology
Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.