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Pathogenic Role of Glutamate in Hyperthermia‐Induced Seizures
Author(s) -
Morimoto Takehiko,
Nagao Hideo,
Yoshimatsu Makoto,
Yoshida Kazuhiro,
Matsuda Hiroshi
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02585.x
Subject(s) - glutamate receptor , neuroscience , hyperthermia , epilepsy , medicine , clinical neurology , psychology , receptor
Summary: Hyperthermia induces seizures in both humans and rodents, but the underlying mechanism remains unknown. The present study showed that hyperthermia, causing rapid increase in body temperature, increases the concentration of glutamate (Glu) released into a cortical perfusate before onset of seizures in rats and that this increase in Glu concentration correlated with a decrease in seizure threshold temperature. These results indicate that increased cortical extracellular Glu induced by hyperthermia contributes to onset of seizures. The same mechanism may be involved in clinical seizures induced by fever in patients with febrile convulsions or epilepsy.