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Anticonvulsant Effect of Fluoxetine on Focally Evoked Limbic Motor Seizures in Rats
Author(s) -
Prendiville S.,
Gale K.
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02425.x
Subject(s) - anticonvulsant , neuroscience , fluoxetine , limbic system , epilepsy , medicine , psychology , motor cortex , serotonin , central nervous system , receptor , stimulation
Summary: Fluoxetine was evaluated for anticonvulsant effects in a rat model of focally evoked complex partial seizures (CPS) secondarily generalized. Fluoxetine was administered intraperitoneally (i.p.) 1 h before seizures were induced by focal intracerebral application of the GABA A receptor antagonist, bicuculline methiodide (118 pmol) unilaterally into a discrete epileptogenic site in the deep prepiriform cortex (“area tempestas,” AT) of rats. Significant dose‐dependent protection from clonic motor seizures was obtained after 5‐, 10‐, and 20‐mg/kg doses of fluoxetine, with 50% protection occurring after the 5‐mg/kg dose. Suppression of electrographic seizure activity was concomitant with suppression of motor seizures. These observations support and extend previous findings of other investigators who showed that fluoxetine exerts anticonvulsant actions against maximal electroshock (MES) convulsions and audiogenic convulsions in genetically seizure‐prone rodents.