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Vigabatrin (γ‐Vinyl‐GABA): Neuropathologic Evaluation in Five Patients
Author(s) -
Sivenius J.,
Paljärvi L.,
Vapalahti M.,
Nousiainen U.,
Riekkinen P. J.
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02398.x
Subject(s) - vigabatrin , neuroscience , medicine , anticonvulsant , epilepsy , psychology
Summary: We performed neuropathologic examination of cerebral cortex specimens from 4 patients who underwent epilepsy surgery and the brain of 1 patient who died suddenly. All had severe epilepsy and had received γ‐vi‐nyl‐GABA (GVG, vigabatrin) for 3–5.5 years. Neither the surgically resected temporal lobe specimens nor the frontal and temporal lobes autopsy specimens showed abnormal white matter vacuolation.