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Clarithromycin‐Carbamazepine Interaction: A Case Report
Author(s) -
Albani Fiorenzo,
Riva Roberto,
Baruzzi Agostino
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02391.x
Subject(s) - carbamazepine , clarithromycin , metabolite , pharmacology , drug interaction , concomitant , antibiotics , medicine , anticonvulsant , pharmacokinetic interaction , chemistry , pharmacokinetics , epilepsy , biochemistry , psychiatry
Summary: We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10‐day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ‐E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.