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Phenytoin Monitoring in Status Epilepticus in Infants and Children
Author(s) -
Richard M. O.,
Chiron C.,
D'Athis P.,
Rey E.,
Aubourg P.,
Dulac O.,
Olive G.
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02387.x
Subject(s) - status epilepticus , phenytoin , anesthesia , medicine , plasma concentration , anticonvulsant , epilepsy , partial seizures , plasma levels , pediatrics , psychiatry
Summary: Two successive protocols of phenytoin (PHT) plasma concentration monitoring were tested in 60 children with status epilepticus (SE). In each protocol, a loading dose of 15 mg/kg was injected and followed by three injections during the first 24 h. Clinical evaluation was performed at the end of the study by grouping patients into three classes according to seizure frequency during treatment: complete effect, partial effect, and no effect. In protocol 1, a complementary dose at the fourth hour was adjusted from individual plasma concentrations. Plasma concentrations at the 40th hour were within the therapeutic range in the 19 patients with complete effect (CE, mean 19 mg/L) and in the 5 patients with no effect (NE, mean 23 mg/L) whereas in the 11 patients with partial effect (PE), plasma concentrations were higher (mean Received July 1991; revision accepted March 1992.