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Convulsions Induced by Methyl β‐Carboline‐3‐Carboxylate in Mice: Effects of Preceding Saline Injections
Author(s) -
Martin Benoît,
Venault Patrice,
Chapouthier Georges
Publication year - 1993
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1993.tb02125.x
Subject(s) - convulsant , saline , sensitization , pharmacology , ratón , benzodiazepine , convulsion , gabaa receptor , chemistry , anesthesia , receptor , medicine , biology , epilepsy , immunology , neuroscience
Summary: The convulsant effects of a high (5 mg/kg intraperitoneally, i.p.) dose of benzodiazepine (BZD) receptor ligand methyl β‐carboline‐3‐carboxylate (β‐CCM), whether or not preceded by administration of two lower doses of β‐CCM (0.5 and 1 mg/kg i.p.) or of saline were studied in nine inbred mouse strains. In five of the strains (A/J, BALB/cBy, C3H/HeJ, CBA/H, and DBA/2J), neither saline nor preceding injections of β‐CCM had any effect on subsequent reactivity to the subsequent convulsant dose. In the other 4 strains, such injections induced either tolerance (CPB‐K, NZB), or sensitization (C57BL/6J, XLII), whatever the compound subsequently administered (β‐CCM or saline). In these strains, the data rule out any tolerance or sensitization effect due to β‐CCM, but suggest that such effects could be due to injection itself.