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Increased pH and Seizure Foci Inorganic Phosphate in Temporal Demonstrated by [ 31 P]MRS
Author(s) -
Laxer Kenneth D.,
Hubesch Bruno,
SappeyMarinier Dominique,
Weiner Michael W.
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02337.x
Subject(s) - epilepsy , temporal lobe , pathophysiology , alkalosis , inorganic phosphate , chemistry , neuroscience , endocrinology , medicine , phosphate , psychology , biochemistry , acidosis
Summary: To investigate alterations of brain metabolism associated with temporal lobe epilepsy, [ 31 P]MRS studies were performed on the anterotemporal lobes of patients with medically refractory complex partial seizures. Interictally, the pH was significantly more alkaline in the temporal lobe ipsilateral to the seizure focus (7.25 vs. 7.08, p < 0.05), and the inorganic phosphorous concentration was greater on the side of the epileptogenic focus (1.9 vs. 1. 1 mM, p < 0.05). These changes in pH and inorganic phosphate may represent metabolic alterations secondary to seizures. Alternatively, because alkalosis enhances neural excitability and may enhance seizure activity, the increased pH of the seizure focus may provide insight into the pathophysiologic mechanism of epileptic seizures.