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Effect of Acute Doses of Controlled‐Release Carbamazepine on Clinical, Psychomotor, Electrophysiological, and Cognitive Parameters of Brain Function
Author(s) -
Meyden C. H.,
Bartel P. R.,
Sommers De K.,
Blom M.,
Becker P.,
Erasmus S.,
Griesel D.
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02324.x
Subject(s) - carbamazepine , electrophysiology , psychomotor learning , cognition , medicine , anticonvulsant , brain function , neuroscience , psychology , anesthesia , epilepsy
Summary: The neurotoxic effect of acute doses of carbamazepine controlled‐release (CBZ‐CR) divitabs (800, 1,200, and 1,600 mg) was assessed on clinical, psychomotor, electrophysiological, and cognitive parameters of brain function in 10 healthy volunteers in a double‐blind, randomised, placebo‐controlled, phase I study. Significant changes compared to placebo were demonstrated for the clinical scales, ataxia (AT), convergence of the nearpoint (CNP), peak saccadic velocity (PSV), critical flicker fusion (CFF), spectral analysis of the EEG, and brainstem auditory evoked potential (BAEP) tests. Digit repetition, digit symbol substitution, Sternberg memory scanning time, Sternberg choice reaction time, saccadic latency, and saccadic accuracy showed important negative findings. Significant clinical tolerance to side effects developed within 20 to 33 h after CBZ‐CR dosage during a period in which the mean CBZ blood levels remained virtually unchanged. CBZ‐CR, 800, 1,200, and 1,600 mg yielded low, medium, and high therapeutic blood levels, respectively, for + 10 to + 33 h after dosage without the development of severe clinical side effects.