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The Effect of Chronic Phenytoin Treatment on Serum Lipid Profile in Adult Epileptic Patients
Author(s) -
Calandre Elena Pita,
Porta Blanca Sinués,
Calzada Dolores García
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02299.x
Subject(s) - phenytoin , apolipoprotein b , medicine , endocrinology , cholesterol , lipoprotein , epilepsy , high density lipoprotein , chemistry , psychiatry
Summary: Total cholesterol, high‐density lipoprotein (HDL), low‐density lipoprotein (LDL), and very‐low‐density lipoprotein cholesterol, apolipoproteins A, A and B and gamma‐glutamyltransferase (ggt) serum concentrations were measured in 100 adult epileptic patients receiving chronic phenytoin (PHT) treatment and in 100 control subjects. In relation to controls, patients showed higher HDL cholesterol, apolipoproteins A and A, and ggt levels and lower LDL cholesterol and apolipoprotein B values; the significance of the results was greater in women than in men. Among patients, ggt levels were positively correlated with PHT plasma concentrations; likewise, a negative correlation was found between the apolipoprotein A/A, ratio and the PHT and ggt plasma levels, and a positive correlation between the apolipoprotein AIA, ratio and the LDL/HDL cholesterol ratio. These data indicate that PHT exerts a beneficial effect on the serum lipids profile.