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Hippocampal Pyramidal Cell Loss in Human Status Epilepticus
Author(s) -
DeGiorgio Christopher M.,
Tomiyasu Uwamie,
Gott Peggy S.,
Treiman David M.
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02278.x
Subject(s) - status epilepticus , hippocampal formation , epilepsy , pyramidal cell , hippocampus , hippocampal sclerosis , medicine , anesthesia , hypoxia (environmental) , neuroscience , temporal lobe , psychology , chemistry , organic chemistry , oxygen
Summary: A pilot case‐control quantitative study of the hippocampus in patients with severe status epilepticus was performed to identify specific patterns of pyramidal cell loss. Pyramidal cell densities from five patients who died following status epilepticus were compared with five normal controls and five controls matched for age, hypoxialischemia, previous epilepsy, and alcohol abuse. Neuronal densities were greatest in the normal control group and least in patients with status epilepticus. Significant reductions were identified in Sommer's sector (prosubiculum and CA1) as well as in CA3 when compared to normal controls.