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Analysis of B 10.D2 Recombinant Congenic Mouse Strains Shows That Audiogenic and β‐CCM‐Induced Seizures Depend on Different Genetic Mechanisms
Author(s) -
Martin Benoit,
Chapouthier Georges,
Motta Roland
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02276.x
Subject(s) - congenic , recombinant dna , biology , genetics , neuroscience , psychology , gene
Summary: The rate of occurrence of audiogenic seizures and seizures induced by the benzodiazepine receptor inverse agonist methyl‐β‐carboline‐3‐carboxylate (β‐CCM) were analyzed in several recombinant congenic strains of mice bred from B10.D2 and DBA/2J. Although both types of seizures have similar behavioral patterns and might involve GABAergic mechanisms, no correlation was observed between the occurrence of the two types of seizures across the strains, suggesting that these two types of seizures depend on different genetic mechanisms.