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Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action
Author(s) -
Ames James R.,
Kovacic Peter,
Kadaba Pankaja K.,
Kiser Patrick F.
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb02204.x
Subject(s) - anticonvulsant , epilepsy , chemistry , zonisamide , electron transfer , mode of action , electrochemistry , in vivo , electron acceptor , pharmacology , neuroscience , combinatorial chemistry , medicine , psychology , photochemistry , biochemistry , biology , microbiology and biotechnology , electrode , topiramate
Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.