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N‐Methyl‐ d ‐Aspartate Injection Into the Massa Intermedia Facilitates Development of Limbic Kindling in Rats
Author(s) -
Hirayasu Y.,
Wada J. A.
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb01745.x
Subject(s) - kindling , nmda receptor , amygdala , limbic system , convulsion , hippocampus , endocrinology , medicine , neuroscience , chemistry , kindling model , thalamus , psychology , epilepsy , receptor , central nervous system
Summary The effect on limbic kindling of N‐methyl‐D‐ aspartate (NMDA) injection into the midline thalamus of rats was investigated. Repeated injection of 25 nmol/0.5 pl NMDA (experimental group) into the massa intermedia (MI), particularly into the reuniens nucleus, caused tonic and/or clonic generalized convulsion associated with temporal limbic EEG seizure discharge. This did not occur after injection of phosphate‐buffered saline (PBS, control group). When the animals were subjected to sub‐sequent kindling at either the hippocampus (HP) or the amygdala (AM), only the experimental group showed a significant facilitation of kindling rate. The results suggest that an NMDA receptor in the reuniens nucleus participates in modulation of temporal limbic excitability and seizure development.