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Changes in the Strength of Recurrent Inhibition in Cobalt‐Induced Epilepsy
Author(s) -
Kawakami Yoriko,
Koyama Ikuko
Publication year - 1992
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1992.tb01686.x
Subject(s) - stimulation , epilepsy , neuroscience , somatosensory system , cats , cortical spreading depression , electroencephalography , thalamus , anesthesia , psychology , chemistry , medicine , migraine
Summary: Changes in the strength of recurrent inhibition in the feline cortex in cobalt (CoCl 2 )‐induced epilepsy were observed. The strength of inhibition was analyzed in terms of paired‐pulse depression of the amplitude of somatosensory evoked potentials (SEPs) elicited by stimulation of the ventral posterolateral (VPL) thalamic nucleus. An enhancement in recurrent inhibition was observed shortly after CoCl 2 application. The size of the amplitude of cortical evoked potentials (EPs) elicited by VPL stimulation increased simultaneously. The reduction of inhibition that appeared later was associated with after discharges (ADS) evoked by VPL stimulation. These ADS frequently extended to epileptic discharges. These results suggest that the reduction in recurrent inhibition induced by CoCl 2 application plays an important role in the spread of seizure activity.