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Adjunctive Therapy for Intractable Epilepsy with Ethotoin
Author(s) -
Biton Victor,
Gates John R.,
Ritter Frank J.,
Loewenson Ruth B.
Publication year - 1990
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1990.tb05499.x
Subject(s) - epilepsy , medicine , retrospective cohort study , tonic (physiology) , adjunctive treatment , intractable epilepsy , pediatrics , central nervous system disease , population , anesthesia , surgery , psychiatry , environmental health
Summary: In a retrospective study, records of 46 patients (24 women and 22 men aged 17–51 years; mean 29.2 years), who had been treated with ethotoin (EHN) as adjunctive therapy for control of intractable seizures were reviewed. Overall, ∽51% of this highly selected patient population had a reduction >50% in overall seizure frequency 1 month after initiation of treatment. This was reduced to ∽25% for the last 3 months of follow‐up (mean follow‐up period 10.6 months). Tonic seizure frequency was reduced most dramatically, by >50%, in 60% of patients at 1 month and in 35% of patients for the last 3 months of follow‐up. This study suggests that prospective controlled trials of EHN, especially for tonic seizures, are needed.