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Pharmacokinetic Effects of Vigabatrin on Cerebrospinal Fluid Amino Acids in Humans
Author(s) -
BenMenachem Elinor
Publication year - 1989
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1989.tb05826.x
Subject(s) - vigabatrin , cerebrospinal fluid , homovanillic acid , dosing , chemistry , pharmacokinetics , pharmacology , anticonvulsant , biogenic amine , antiepileptic drug , chromatography , epilepsy , neurotransmitter , medicine , biochemistry , serotonin , receptor , psychiatry
Summary: A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug‐resistant complex partial seizures. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homocarnosine, homovanillic acid (HVA), GVG, and 5‐ hydroxyindolacetic acid were measured up to seven days after a single dose. GVG levels were maximal within 24 h, suggesting that GVG acts to inhibit GABA‐transami‐nase, and may also increase biogenic amines.