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Hepatotoxicity in Rat Following Administration of Valproic Acid: Effect of L‐Carnitine Supplementation
Author(s) -
Sugimoto Tateo,
Araki Atsushi,
Nishida Naoki,
Sakane Yoshimi,
Woo Man,
Takeuchi Taishi,
Kobayashi Yohnosuke
Publication year - 1987
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1987.tb03660.x
Subject(s) - carnitine , valproic acid , endocrinology , medicine , saline , mitochondrion , pharmacology , anticonvulsant , chemistry , epilepsy , biochemistry , psychiatry
Summary: The effect of prolonged administration (7 days) of valproate (VPA, 500 mg/kg/day), or VPA (500 mglkglday) with L‐carnitine (200 mg/kg/day) on blood carnitine levels and the appearance of liver mitochondria were assessed in the rat. VPA‐treated rats showed hypo‐ carnitinemia and enlarged mitochondria when compared with saline‐injected control rats. In rats treated with bothVPA and L‐carnitine, serum and liver carnitine levels were increased by the L‐carnitine supplement and the liver mitochondria were not enlarged. L‐Carnitine supplement in VPA‐medicated patients seems to prevent hepatotoxicity, especially mitochondrial dysfunction.