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Open Trials with Valproate in Epilepsy
Author(s) -
Dulac Olivier,
Arthuis Michel
Publication year - 1984
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1984.tb05633.x
Subject(s) - valproic acid , epilepsy , anticonvulsant , medicine , clinical neurology , pediatrics , psychiatry , psychology , neuroscience
Valproic acid (VPA) was first synthesized in the United States (Burton, 1882) and was used worldwide for 80 years as an organic solvent. Its unexpected antiepileptic activity was discovered 20 years ago in Grenoble, France (Meunier et al., 1963; Carraz et al., 1964). The aim of this work is to report the progressive evolution of ideas and the clinical approach to the treatment of epilepsy with sodium valproate (Na VPA) and VPA, according to published open trials and to our own unpublished data.