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Valproic Acid: Reversibly Acting Drug?
Author(s) -
Lockard Joan S.,
Levy René H.
Publication year - 1976
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1976.tb04459.x
Subject(s) - valproic acid , drug , antiepileptic drug , pharmacology , chemistry , anesthesia , anticonvulsant , epilepsy , medicine , psychiatry
Summary Valproic acid [dipropylacetic acid (DPA)] was evaluated in an alumina‐gel monkey model ( N = 12) by constant‐rate intravenous infusion. The data indicated: (a) a statistically significant decrease in seizure frequency the first 2 days of drug Step I (45–55 μg/ml) and drug Step II (90–110 μg/ml) which was temporary, lasting 2 days only; (b) a later, more permanent decrease in seizure frequency which was not apparent until drug Step III (130–170 μg/ml); and a delayed return of the seizure frequency to predrug levels for 2 weeks after drug administration was discontinued, with no DPA detectable in plasma after the initial postdrug day. Whether DPA will behave as a reversibly acting drug was discussed.