Premium
Inter‐relations of Folic Acid and Vitamin B 12 in Drug‐treated Epileptic Patients
Author(s) -
REYNOLDS E. H.,
WRIGHTON R. J.,
JOHNSON A. L.,
PREECE J.,
CHANARIN I.
Publication year - 1971
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1971.tb03929.x
Subject(s) - folic acid , anticonvulsant , medicine , epilepsy , vitamin b , anticonvulsant drugs , vitamin , drug , gastroenterology , pharmacology , psychiatry
SUMMARY During treatment with folic acid, 15 mg daily for 2 years, serum vitamin B 12 levels fell in 24 out of 30 epileptic patients treated with anticonvulsant drugs. The most rapid fall occurred in the first 3 months of folate therapy, from a mean of 360 pg/ml to 221 pg/ml, but it continued more slowly for up to 15 months, or longer in some. In 10 of 11 patients in whom folic acid therapy was stopped but anticonvulsant therapy continued; serum folate levels subsequently fell to subnormal values within 18 months.