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Excitability Changes throughout the Neocortex induced by a Localized Spiking Focus
Author(s) -
CRIGHEL E.,
DIMOV S.
Publication year - 1967
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1967.tb03818.x
Subject(s) - neocortex , neuroscience , strychnine , convulsant , gyrus , mescaline , psychology , medicine , pharmacology , receptor , hallucinogen
SUMMARY Topical application of convulsive drugs (mescaline or strychnine) elicited a spiking by direct cortical responses (DCR). The evolution of the spiking focus is accompanied also by generalized excitability changes. The sense and intensity of excitability changes throughout the neocortex depends on the site of topical application of convulsant drugs. A focus in the ectosylvian gyrus induces the most important changes, especially in the homolateral marginal gyrus. A direct pathway between these two is evident. RÉASUMÉA Topical application of convulsive drugs (mescaline or strychnine) elicited a spiking focus at the application level. The focus onset is preceded by general excitability changes, appearing from the study of evoked responses to peripheral stimuli (ER) and by direct cortical responses (DCR). The evolution of the spiking focus is accompanied also by generalized excitability changes. The sense and intensity of excitability changes throughout the neocortex depends on the site of topical application of convulsant drugs. A focus in the ectosylvian gyrus induces the most important changes, especially in the homolateral marginal gyrus. A direct pathway between these two is evident. RÉASUMÉA L'application locale de substances convulsivantes (mescaline, strychnine) sur le cortex provoque un foyer de pointes au point d'application. L'apparition de ce foyer et son eAvolution sont preAceAdeAes et accompagneAes par des modifications geAneArales de l'excitabiliteA mises en eAvidence par l'eAtude des reAponses eAvoqueAes par des stimuli peAripheAriques ou une stimulation corticale directe. Le sens et l'intensiteA de toutes ces modifications de l'excitabiliteA geAneArale aG travers le neocortex deApendent du lieu d'application de la substance convulsivante. Un foyer dans le gyrus ectosylvien produit les modifications les plus importantes, principalement dans le gyrus marginal homolateral, ce qui met en eAvidence une voie directe entre ces ceux gyri.