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Clinical and Experimental Aspects of Barbiturate Withdrawal Convulsions
Author(s) -
ESSIG C. F.
Publication year - 1967
Publication title -
epilepsia
Language(s) - French
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1967.tb03816.x
Subject(s) - barbiturate , anesthesia , abstinence , reticular formation , medicine , psychology , psychiatry , central nervous system
SUMMARY Clinical and experimental data concerning mechanisms underlying barbiturate withdrawal convulsions have been reviewed. Such abstinence seizures have occurred in decorticate and decerebellate dogs. The possible role of the reticular activating system in the origin of this convulsive process was discussed. An increase in neuronal excitability probably develops during barbiturate withdrawal, but a biochemical basis for this has not been proven. RÉASUMÉA Les donneAes cliniques et expeArimentalesconcernant les meAcanismes responsables des convulsions secondaires au sevrage barbiturique sont passeAes en revue. Des crises de ce type peuvent s'observer chez des chiens deAcortiqueAs et deAceAreAbelleAs. Le roCle possible du systeGme reAticuleA activateur aG l'origine de ces crises est discuteA. Une augmentation de l'excitabiliteA neuronique se deAveloppe probablement pendant le sevrage barbiturique mais une base biochimique n'a pas eAteA deAmontreAe aG l'origine de cette hyperexcitabiliteA.