Open AccessMarkers of Cardiac Collagen Turnover Are Similar in Patients With Mild and More Severe Symptoms of Heart Failure
Author(s) -
Cavallari Larisa H.,
Groo Vicki L.,
Momary Kathryn M.,
Stamos Thomas D.,
Vaitkus Paul T.
Publication year - 2007
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1527-5299.2007.07217.x
Subject(s) - medicine , heart failure , n terminal telopeptide , interquartile range , myocardial fibrosis , cardiology , cardiac fibrosis , pathophysiology , fibrosis , aldosterone , heart disease , biochemistry , chemistry , alkaline phosphatase , osteocalcin , enzyme
Cardiac fibrosis plays an important role in the pathophysiology of heart failure. The authors sought to determine whether biomarkers of cardiac fibrosis for milder clinical degrees of heart failure are comparable to those of more advanced disease. Procollagen types I and III amino‐terminal peptides (PINP and PIIINP) and type I collagen telopeptide (ICTP) were compared between aldosterone‐antagonistnaive patients with heart failure and New York Heart Association class I or II (n=22/23) and class III or IV (n=42/3) symptoms. Median (interquartile) range concentrations of PINP (63.3 [44.2–88.8] vs 48.6 [37.8–74.9] µg/L), ICTP (7.0 [5.4–16.8] vs 6.5 [4.7–12.7] µg/L), and PIIINP (4.7 [3.2–7.0] vs 4.7 [2.9–7.3] µg/L) were comparable between patients with mild and moderate to severe disease, respectively. These data suggest that patients with mild heart failure may have similar degrees of cardiac fibrosis to patients with more severe disease and support the examination of antifibrotic therapy, including aldosterone antagonists, in milder degrees of heart failure.