Open AccessObese Patients Have Lower B‐Type and Atrial Natriuretic Peptide Levels Compared With Nonobese
Author(s) -
Khush Kiran K.,
Gerber Ivor L.,
McKeown Barry,
Marcus Gregory,
Vessey Joshua,
Foster Elyse,
Chatterjee Kanu,
Michaels Andrew D.
Publication year - 2006
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1527-5299.2006.04900.x
Subject(s) - medicine , natriuretic peptide , atrial natriuretic peptide , heart failure , cardiology , body mass index , ejection fraction , hemodynamics , endocrinology , brain natriuretic peptide
Obesity is a risk factor for the development of heart failure, but the causal mechanism remains unclear. Impaired production or enhanced clearance of natriuretic peptides, which regulate sodium balance and sympathetic activation, may play an important role. The authors investigated the relationship of plasma B‐type natriuretic peptide and atrial natriuretic peptide levels to body mass index in 100 patients referred for left heart catheterization. Hemodynamic and echocardiographic data were obtained for all study participants. Atrial natriuretic peptide and B‐type natriuretic peptide levels were compared in obese (body mass index ≥30 kg/m 2 ) and nonobese (body mass index <30 kg/m 2 ) subjects. Multivariate regression analyses were performed, adjusting for clinical and hemodynamic covariates. Obese patients had significantly lower B‐type natriuretic peptide ( p= 0.03) and atrial natriuretic peptide ( p= 0.04) levels compared with nonobese. Multivariate analysis revealed lower B‐type natriuretic peptide ( p= 0.095) and atrial natriuretic peptide (p=0.007) levels in obese patients while controlling for age, sex, left ventricular end‐diastolic pressure, and left ventricular ejection fraction. Low levels of circulating natriuretic peptides are thus associated with obesity and may contribute to the development of heart failure.