Open AccessStem Cell Therapy for the Heart
Author(s) -
Wold Loren E.,
Dai Wangde,
Sesti Casilde,
Hale Sharon L.,
Dow Joan S.,
Martin Bradley J.,
Kloner Robert A.
Publication year - 2004
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1527-5299.2004.04276.x
Subject(s) - medicine , stem cell , myocardial infarction , bone marrow stem cell , stem cell therapy , bone marrow , myocyte , heart failure , cell type , cell therapy , cell , cardiology , bioinformatics , mesenchymal stem cell , pathology , microbiology and biotechnology , biology , genetics
Cellular cardiomyoplasty is an expanding field of research that involves numerous types of immature cells administered via several modes of delivery. The purpose of this review is to investigate the benefits of different types of cells used in stem cell research as well as the most efficient mode of delivery. The authors also present data showing that stem cells isolated from bone marrow are present at both 2 weeks and 3 months after engraftment in a myocardial infarction. These cells express muscle markers at both time points, which suggests that they have begun to differentiate into cardiomyocytes. Several questions must be answered, however, before stem cells can be used routinely in the clinic. Once these questions have been addressed, the use of stem cells in clinical practice can be realized.