Open AccessReproducibility of Impedance Cardiography Hemodynamic Measures in Clinically Stable Heart Failure Patients
Author(s) -
Greenberg Barry H.,
Hermann Denise D.,
Pranulis Maryann F.,
Lazio Lucia,
Cloutier David
Publication year - 2000
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1527-5299.2000.80140.x
Subject(s) - medicine , impedance cardiography , heart failure , hemodynamics , cardiology , stroke volume , cardiac index , population , cardiac output , reproducibility , contractility , heart rate , physical therapy , ejection fraction , blood pressure , environmental health , statistics , mathematics
Background and Aims. One of the greatest challenges confronting physicians who are managing the care of patients with heart failure is to acquire objective data that signals treatment effectiveness and/or disease progression. The aim of this study was twofold: 1) to determine the extent to which (real time) impedance cardiography measurements obtained with a specific medical device (the BioZ®) were reproducible in outpatients with clinically stable heart failure; and 2) to establish “normal” ranges of one week hemodynamic variability in this population of patients. Information of this nature would help clinical cardiologists and primary care practitioners to evaluate the implications of their patient's visit‐to‐visit hemodynamic variability.Methods. A one group, prospective, time series design was used. The sample consisted of 62 patients who had clinically stable heart failure and who were being treated in an outpatient heart failure clinic at a university medical center. BioZ® hemodynamic measures of cardiac output, contractility, and after load were obtained at five points in time: two, 10, and 60 minutes resting following a 40–50 foot walk on the first day and at two and 10 minutes resting following a 40–50 foot walk on the second day, one week later.Results. Small but significant changes in cardiac output and cardiac index (mainly due to changes in heart rate) were seen during the 60 minute period on week one. Stroke index did not change during this period. In general, reproducibility between measurements taken on the same day and between days was quite good. Establishment of 95% confidence intervals helped define boundaries of variability in this population. Further clinical evaluation of the four patients whose values exceeded the 95% confidence intervals revealed unexpected, potentially relevant changes that could have accounted for their interday variability. Conclusion. The BioZ® impedance cardiography measurements are responsive to hemodynamic activity‐rest changes and are reproducible at a one week interval in clinically stable heart failure patients being treated in an outpatient clinic. Stroke index is a better measure of patient status than cardiac output or cardiac index.