Open AccessCardiovascular Properties of Yangambin, a Lignan Isolated from Brazilian Plants
Author(s) -
Tibiriçá Eduardo
Publication year - 2001
Publication title -
cardiovascular drug reviews
Language(s) - English
Resource type - Journals
eISSN - 1527-3466
pISSN - 0897-5957
DOI - 10.1111/j.1527-3466.2001.tb00073.x
Subject(s) - platelet activating factor , phosphorylcholine , endotoxic shock , pharmacology , septic shock , medicine , lignan , biological activity , shock (circulatory) , chemistry , biology , sepsis , biochemistry , in vitro , botany
Yangambin was initially selected from a number of lignans isolated from Brazilian plants for its ability to antagonize Platelet‐Activating Factor (PAF, 1‐ O ‐hexadecyl‐2‐acetyl‐sn‐glyceryl‐3‐phosphorylcholine)‐induced biological effects. Subsequently it was shown that, besides its antagonistic properties at PAF receptors, yangambin also prevents the cardiovascular collapse observed during anaphylactic and endotoxic/septic shocks, as well as the vascular and cardiac hyporesponsiveness to catecholamines in endotoxic shock. It is suggested that this naturally occurring compound could be of potential interest in the adjunctive management of the above mentioned pathologies. In the present article, we review the main studies investigating the pharmacological properties of yangambin related to the cardiovascular function.