Open AccessCilnidipine: Preclinical Profile and Clinical Evaluation
Author(s) -
Uneyama Hisayuki,
Uchida Hirohisa,
Konda Tomoyuki,
Yoshimoto Ryota
Publication year - 1999
Publication title -
cardiovascular drug reviews
Language(s) - English
Resource type - Journals
eISSN - 1527-3466
pISSN - 0897-5957
DOI - 10.1111/j.1527-3466.1999.tb00024.x
Subject(s) - reprint , basic research , library science , medicine , engineering , computer science , physics , astronomy
channels and neuronal cells at the level of N-type Ca 2+ channels. The L-type Ca 2+ channel blockade by cilnidipine affects predominantly vascular smooth muscle, thereby producing vasodilation of peripheral resistance vessels and coronary arteries. The blockade of N-type Ca channels affects predominantly peripheral nerve endings of sympathetic neurons, thereby dilating blood vessels by lowering plasma catecholamine levels. Cilnidipine produced greater reductions in blood pressure in patients with hypertension than in healthy volunteers. Although increases in heart rate were noted in studies with conventional L-type selective DHPs, the changes in heart rate with cilnidipine were negligible, even in patients with rapid blood pressure reduction. Thus, it appears that the hypotension-induced baroreflex sympathetic stimulation is attenuated by this inhibitory action on N-type Ca 2+